Gemfibrozil enhances the listeriacidal effects of fluoroquinolone antibiotics in J774 macrophages.
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Gemfibrozil enhances the listeriacidal effects of fluoroquinolone antibiotics in J774 macrophages
J774 macrophage-like cells express organic anion transporters that promote the efflux of fluoroquinolone antibiotics such as norfloxacin (NFX) from these cells. Gemfibrozil (GFZ) blocks organic anion transport in J774 cells, thereby facilitating the intracellular accumulation of NFX (Cao, C., H.C. Neu, and S.C. Silverstein. 1991. J. Cell Biol. 115:467a [Abstr.]). To determine whether GFZ enhanc...
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Changes in the expression of MDR transporters in J774 mouse macrophages selected by chronic exposure to ciprofloxacin (CIP) or moxifloxacin (MXF), two fluoroquinolone antibiotics
C. Vallet, B. Marquez, N. Nhiri*, E. Jacquet*, M-P. Mingeot-Leclercq, P.M. Tulkens, F. Van Bambeke Unité de pharmacologie cellulaire et moléculaire, Université catholique de Louvain, Brussels, Belgium *Institut de chimie des substances naturelles, CNRS, Gif sur Yvette, France Mailing address : P.M. Tulkens, Pharmacologie cellulaire et moléculaire, UCL Bat. Van Helmont, 7370 Av. E. Mounier,1200 ...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1992
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.176.5.1439